منابع مشابه
Corneal allograft rejection.
The cornea is avascular, enjoys relative immune privilege, and immunosuppressive treatment can be directly applied: yet data from all available reports indicate that allogeneic rejection is the commonest cause of corneal graft failure. In Australia, 5 year actuarial corneal graft survival is 72%: irreversible rejection accounts for at least 33% of all graft failures.' Graft survival is much sho...
متن کاملCorneal Allograft Rejection: Immunopathogenesis to Therapeutics
Corneal transplantation is among the most successful solid organ transplants. However, despite low rejection rates of grafts in the 'low-risk' setting, rejection can be as high as 70% when grafted into 'high-risk' recipient beds. Under normal homeostatic conditions, the avascular cornea provides a unique environment that facilitates immune and angiogenic privilege. An imbalance in pro-inflammat...
متن کاملEffect of Fas -670 A/G Gene Polymorphism on Corneal Allograft Endothelial Rejection
Background: Human cornea expresses functional Fas-ligand capable of killing Fas+ activated lymphocytes. Fas expression is partly regulated by -670 A/G polymorphism in the promoter region of Fas gene. Objective: The aim of the present study is to determine the association between Fas-670A/G polymorphism and survival of corneal transplantation. Methods: In 276 graft recipients who mainly underwen...
متن کاملCorrelation of Corneal Allograft Rejection with Tumor Necrosis Factors-Alpha Gene Polymorphism
Background: Correlations between bone marrow, heart, kidney, liver, skin and lung transplant rejection or survival with human cytokine gene polymorphisms have been described. There are also reports about the role of cytokines and Tumor Necrosis Factors-Alpha (TNF-α) on corneal transplant in animal models. Further studies are needed to clarify the role of cytokines in corneal allograft rejection...
متن کاملLocal gene transfer to modulate rat corneal allograft rejection.
PURPOSE Allograft rejection is the leading cause of corneal graft failure. CD4(+) T cells control the allograft response and represent targets for antirejection therapy. The purpose of this study was to transfer cDNA encoding a monomeric anti-CD4 antibody fragment to donor corneal endothelium, to attempt to modulate orthotopic corneal allograft rejection in the rat. METHODS A replication-defi...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 1994
ISSN: 0007-1161
DOI: 10.1136/bjo.78.8.649